The Laboratory Timeline

Architecture for Scientific Research

Past, Present & Future

The Laboratory Timeline was born from a few fundamental questions. As architects, we had noticed that the lab building typology had not been comprehensively researched and that the available literature on the subject was scattered. We felt compelled to investigate this typology and the ways it has been shaped by research priorities and architectural ambitions over time, and we began by asking:

How have research labs evolved from solitary spaces in unlikely locations to the scientific communities and major segments of institutional fabric that they are today?

What can be learned from labs designed and built in previous generations, and even within the past decade, to best inform our building designs?

What is happening now in scientific research that can help shape the labs of the future?

Prologue

1 Gregor Mendel’s Lab—a monastery garden, 1865

2 Rockefeller Institute Medical Research Labs, 1917

3 Leicester University Engineering Labs, 1963

4 Columbia University Neuroscience Labs, 2017

The Lab Timeline examines the building typology from its roots in the mid- to late 19th century, when purpose-built structures for scientific research were just beginning to emerge, to present-day lab buildings, and, finally, ahead to the future. We should be reminded that the architecture for scientific research is only about 160 years old—an extremely young building typology in relation to domestic architecture, temples, churches, theaters, schools, and museums. We have not been at this for very long, and the rapid pace of scientific discovery and inquiry will continue to inform our research buildings of the future. In order to understand what the future may bring for science and research buildings, it’s important to understand how we ended up where we are today. There are two important reasons to examine the architectural evolution of the lab building. The first is that the basic goals and aspirations of the individuals and institutions of the past are often very similar to what they are today but exist under very different technological, institutional, societal, and political conditions. This is meaningful architecturally because we can generate new architectural concepts from historical examples and recondition them to the present. Marie Curie’s “shed lab” in Paris might have been less than ideal—but imagine it reinterpreted today with new conviction and intent. The second is that one can’t ignore that great science and research occurred in certain buildings and spaces that are now legacy and that those environments engendered discovery and invention. Certainly the individual researcher’s imagination or the research group’s collective minds and inquiries played a critical role, but the design of the physical environment must have contributed in some way too. The Lab Timeline therefore tracks the history of scientific discovery and invention alongside the history of lab architecture. The physical location of the “Fly Lab” in Columbia University’s monumental Schermerhorn Hall and the building’s proximity to museological collections as well as other natural-science departments surely played a role in the great discoveries in genetics that occurred there. The lab itself was cramped and tiny, but perhaps that helped accelerate the research by encouraging frequent conversation amongst the research team during their long days in the lab. Can this example be applied to new planning and design ideas for labs today? Perhaps not literally, but certainly the model exists as a source of inspiration.

As architects of lab buildings we are committed to designing and building for the future of science. It’s been said that “the best way to predict the future is to invent it.”1 Invention requires hard work, sustained inquiry, a grounded understanding of what came before, and, perhaps, a bit of luck. We believe architecture can proceed on a similar path to arrive at successful and inventive solutions. The Lab Timeline attempts to capture that spirit of invention and provide inspiration for research labs of the future.

Historical Introduction
The Scientific Method and Early Labs

Aristotle

4th Century BCE

Long before labs existed, the scientific method had to be contemplated. Aristotle—as depicted in Raphael’s painting The School of Athens, at center in blue (next to Plato)—was one of the first great philosophers to ask fundamental questions about nature and to examine the world around him. He is the father of modern science and the scientific method—the process of observation, collection, classification, and discovery. In opposition to Plato, who believed in mysticism and idealism, Aristotle was a realist and empiricist who sought to observe nature through the sober eyes of science.2 He wrote treatises on biology, including the taxonomy of many living organisms, as well as physics and astronomy.

Aristotle set up a school in Athens to rival Plato’s academy: The Lyceum. This was his answer to Plato’s Academy and its mirror image.3 It consisted of a garden, a temple to the nine muses, lecture rooms, a library, and rooms with tables for collecting and dissecting biological specimens.

Alchemy

Alchemist’s chamber, 400 AD–1300 AD

Long before labs existed, the scientific method had to be contemplated. Aristotle—as depicted in Raphael’s painting The School of Athens, at center in blue (next to Plato)—was one of the first great philosophers to ask fundamental questions about nature and to examine the world around him. He is the father of modern science and the scientific method—the process of observation, collection, classification, and discovery. In opposition to Plato, who believed in mysticism and idealism, Aristotle was a realist and empiricist who sought to observe nature through the sober eyes of science.2 He wrote treatises on biology, including the taxonomy of many living organisms, as well as physics and astronomy.

Aristotle set up a school in Athens to rival Plato’s academy: The Lyceum. This was his answer to Plato’s Academy and its mirror image.3 It consisted of a garden, a temple to the nine muses, lecture rooms, a library, and rooms with tables for collecting and dissecting biological specimens.

Experimentation
Chemical Lab, circ. 1750

This continued into the 19th century, when European and American labs often depicted the lone researcher working in less than optimal conditions—in attics, basements, or sheds without much access to natural light or critical services like plumbing and ventilation.Emphasis shifted to experimental reproducibility and rationality.

This continued into the 19th century when labs in Europe and America still often depicted the lone researcher in his or her lab in less than optimal conditions— in attics, basements, or sheds without much access to natural light or critical services like plumbing and ventilation. Scientists began to demand better facilities. Louis Pasteur, one of the great “microbe hunters”6 who brought the world some of the first vaccinations, pasteurization, and (most important?) better wine, was eloquent on this matter and implored politicians and universities for improved facilities. This helped to usher in the purpose-built research lab that could accommodate groups of scientists. The late 19th century saw the lab become visible, recognized, and institutionalized. It is here that The Lab Timeline begins.

Research
Michael Faraday’s lab, London, 1852

I implore you, take some interest in those sacred dwellings meaningly described as laboratories. Ask that they be multiplied and completed. They are the temples of the future, of riches, and of comfort. There humanity grows better, stronger; there she can learn to read the works of nature, works of progress and universal harmony, while humanity’s own works are too often those of barbarism, of fanaticism, and of destruction.

— Louis Pasteur, 1868

The Lab Timeline

Purpose-Built Labs: Mid-19th Century to Present

Biology The Cavendish Laboratory Cambridge, England James Clerk Maxwell, 1874 Thomas Edison Laboratories West Orange, NJ Henry Hudson Holly, 1888 Marie Curie’s “Shed Lab” Paris, France no architect, 1897 Schermerhorn Hall (“fly lab”) Columbia University, New York, NY McKim, Mead & White, 1898 The Einstein Tower Potsdam, Germany Erich Mendelsohn, 1922 MIT RadLab (Building 20) Cambridge, MA McCreery & Theriault, 1943 Rockefeller Institute Flexner Hall New York, NY Coolidge & Shattuck, 1917 Cold Spring Harbor Lab (Jones Lab), Cold Spring Harbor, NY; Sidney Watson (orig. 1895), 1930s Physics & Engineering Scroll over to show milestones in: Biology The Cavendish Laboratory Cambridge, England James Clerk Maxwell, 1874 Thomas Edison Laboratories West Orange, NJ Henry Hudson Holly, 1888 Marie Curie’s “Shed Lab” Paris, France no architect, 1897 Schermerhorn Hall (“fly lab”) Columbia University, New York, NY McKim, Mead & White, 1898 The Einstein Tower Potsdam, Germany Erich Mendelsohn, 1922 MIT RadLab (Building 20) Cambridge, MA McCreery & Theriault, 1943 Rockefeller Institute Flexner Hall New York, NY Coolidge & Shattuck, 1917 Cold Spring Harbor Lab (Jones Lab), Cold Spring Harbor, NY; Sidney Watson (orig. 1895), 1930s Physics & Engineering Scroll over to show milestones in:

The Buildings

The Foundation The Cavendish Lab Cambridge, England 1874 The Cavendish was one of the world's first purpose-built lab buildings, and was designed specifically for experimentation and education in physics. This was before Einstein’s time, but the foundation for his theory of relativity and modern physics was laid here through the research of J.J. Thomsen, Ernest Rutherford, and other physicists. The building was large by 19th century standards and was set within the context of the traditional Victorian campus of Cambridge, surrounded by museums. The choice of a museological setting was deliberate because just prior to this time, engineering and the natural sciences were taught from museum collections. The design and layout of the building embodied the idea of the lab as the center of measurement and calculation. It included three floors of labs and a basement for specialized experiments. The windows were intentionally large to provide steady, bright illumination for experiments. Exterior window platforms were intended for spectroscopes, prisms, and lenses to study the phenomenon of light. The history of discovery at the Cavendish has been nothing less than extraordinary: Nearly 30 Nobel laureates conducted their work here. In 1953, James Watson and Francis Crick, in collaboration with Rosalind Franklin and Maurice Wilkins, elucidated the structure of DNA at the Cavendish. Architect: James Clerk Maxwell The R&D Factory Thomas Edison Laboratories West Orange, NJ 1888 Thomas Alva Edison brought his ambitious plan for a world-class laboratory and research-and-development facility to West Orange, New Jersey, in 1887. He also purchased a large estate and mansion only a couple of miles from his new lab. When it was built, the West Orange lab complex was probably one of the largest in the world. His goals for the lab were as lofty as his inventions: I will have the best equipped and largest facility extant, incomparably superior to any other for rapid and cheap development of an invention, and working it up to commercial shape with models, patterns, and special machinery. The main three-story lab building is 250 feet long and only 50 feet wide. The structure was designed to be flexible and contained shops for both heavy machinery and delicate fine-tooled components, a drafting room, and chemical labs. A two-story library near the entrance served as Edison’s office and meeting location with investors. Four smaller one-story satellite lab structures were situated perpendicular to the main lab. The phonograph, refinement of the electric light-bulb, and magnetic storage batteries were among the hundreds of inventions conceived, developed, and produced here. The main lab building and its satellite labs still stand today as a great model for an R&D incubator. Architect: Henry Hudson Holly The Shed Marie Curie’s “Shed Lab” Paris, France 1897 Marie Curie is likely to remain the only two-time winner of the Nobel Prize to have carried out much of her scientific work in a shed. She was awarded the prizes in both physics and chemistry for her discovery of radioactivity, opening the doors to 20th-century atomic physics. Most scientists did not have room for experimentation at this time and had to make do with marginal spaces in universities, museum basements, or, in many cases, their homes. Both Curie and her husband, Pierre, needed space to conduct their work on the measuring, distilling, and isolation of radioactive elements. They found a shabby unused glass-paneled atelier on the Rue Lhomond in Paris. Curie described it as “a ramshackle hangar...its ceiling was of shaky laths, its windows were ill-fitting and drafty, its taps dripped... the only furniture was a worn pine table, but there was a blackboard...and a cast iron stove with a rusty pipe that gave off a little heat in the winter.” 10 While not ideal, it served its purpose, and it’s worth noting that the shed had some desirable architectural features: high bay space that was open, flexible, and flooded with daylight from an industrial skylight; a little space for interaction at the stove and chalkboard; and direct access to a courtyard so that experiments could be moved outside when necessary. Architect: unknown

Dedication

The Lab Timeline was conceived by Craig M. McIlhenny AIA